Antibody-fused interferons as an effective approach to enhance target specificity and antiviral efficacy of type I interferons
نویسندگان
چکیده
منابع مشابه
Type I Interferons in Newborns—Neurotoxicity versus Antiviral Defense
In most children and adults, primary infection with herpes simplex virus 1 (HSV-1) is asymptomatic. However, very rarely (incidence of 1 in 1,000,000), it can cause herpes simplex encephalitis (HSE). HSE also occurs in infants but with a much starker incidence of one in three. This age difference in susceptibility to HSV-1-caused HSE is not well understood. In a recent article in mBio, authors ...
متن کاملDifferential Effects of the Type I Interferons 4, , and on Antiviral Activity and Vaccine Efficacy
The type I IFNs exert a range of activities that include antiviral, antiproliferative, and immunomodulatory effects. To study this further, we have constructed recombinant vaccinia viruses expressing HIV or hemagglutinin (HA) Ags along with murine type I IFNs, IFN4 (HA-VV-IFN4), IFN(HA-VV-IFN), or IFN(HIV-VV-IFN), a recently discovered member of this family. Our aims were to characterize IFNfun...
متن کاملProduction of type I interferons
Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique...
متن کاملAntiviral defense: interferons and beyond
Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon production and raise important questions regar...
متن کاملType I Interferons as Regulators of Lung Inflammation
Immune responses to lung infections must be tightly regulated in order to permit pathogen eradication while maintaining organ function. Exuberant or dysregulated inflammation can impair gas exchange and underlies many instances of lung disease. An important driver of inflammation in the lung is the interferon (IFN) response. Type I IFNs are antiviral cytokines that induce a large range of prote...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Research
سال: 2008
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2008.304